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LOC126860970 BRD4-independent group 4 enhancer GRCh37_chr10:79743812-79745011 [ Homo sapiens (human) ]

Gene ID: 126860970, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860970
Gene description
BRD4-independent group 4 enhancer GRCh37_chr10:79743812-79745011
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860970 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (77984054..77985253)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (78853092..78854291)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79743812..79745011)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79688206-79688382 Neighboring gene DLG5 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79707975-79708512 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:79708513-79709050 and GRCh37_chr10:79709051-79709588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79730866-79731376 Neighboring gene H2A.Z histone pseudogene 5 Neighboring gene RNA polymerase III subunit A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79784551-79785750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3613 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79799147-79799658 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79799659-79800168 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79800489-79800990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3616 Neighboring gene ribosomal protein S24 Neighboring gene G protein subunit alpha i2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085469.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    77984054..77985253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    78853092..78854291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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