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LOC126860986 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:86028972-86030171 [ Homo sapiens (human) ]

Gene ID: 126860986, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860986
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:86028972-86030171
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860986 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (84269216..84270415)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (85147736..85148935)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:86004955-86005454 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2553 Neighboring gene retinal G protein coupled receptor Neighboring gene long intergenic non-protein coding RNA 858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:86057631-86058131 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:86073792-86074670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17641 Neighboring gene coiled-coil serine rich protein 2 Neighboring gene Sharpr-MPRA regulatory region 13339 Neighboring gene ribosomal protein L12 pseudogene 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085485.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    84269216..84270415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    85147736..85148935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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