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LOC126861041 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:112534241-112535440 [ Homo sapiens (human) ]

Gene ID: 126861041, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861041
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:112534241-112535440
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (110774483..110775682)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (111658238..111659437)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112523918-112524418 Neighboring gene RN7SK pseudogene 288 Neighboring gene RNA, 5S ribosomal pseudogene 327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112571707-112572272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4043 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:112589780-112589960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:112605645-112606144 Neighboring gene uncharacterized LOC124902499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4051 Neighboring gene CRISPRi-validated cis-regulatory element chr10.4148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112619133-112619632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4054 Neighboring gene uncharacterized LOC124902500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4056

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 4042

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085540.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    110774483..110775682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    111658238..111659437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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