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LOC126861045 CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115251436-115252635 [ Homo sapiens (human) ]

Gene ID: 126861045, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861045
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115251436-115252635
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (113491677..113492876)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (114383291..114384490)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115112200-115113399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:115118149-115118913 Neighboring gene RNA, U7 small nuclear 165 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:115141212-115142411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115161035-115161535 Neighboring gene Sharpr-MPRA regulatory region 9752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115213798-115214298 Neighboring gene Sharpr-MPRA regulatory region 1511 Neighboring gene uncharacterized LOC107984270 Neighboring gene peptidylprolyl isomerase A pseudogene 39 Neighboring gene uncharacterized LOC124902504 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:115317286-115317966 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:115317967-115318647 Neighboring gene Sharpr-MPRA regulatory region 9721 Neighboring gene MPRA-validated peak1095 silencer Neighboring gene hyaluronan binding protein 2 Neighboring gene nebulin related anchoring protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085544.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    113491677..113492876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    114383291..114384490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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