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LOC126861092 MED14-independent group 3 enhancer GRCh37_chr10:130427109-130428308 [ Homo sapiens (human) ]

Gene ID: 126861092, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861092
Gene description
MED14-independent group 3 enhancer GRCh37_chr10:130427109-130428308
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861092 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (128628845..128630044)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (129554087..129555286)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2933 Neighboring gene marker of proliferation Ki-67 Neighboring gene NANOG hESC enhancer GRCh37_chr10:129963700-129964282 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:129970982-129972181 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:129999872-130000380 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:130000381-130000888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130007752-130008313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109218-130109718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109719-130110219 Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene uncharacterized LOC124902558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130184885-130185386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130232943-130233444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130238232-130238732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281351-130281852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281853-130282352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130317555-130318446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130318447-130319337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130339525-130340200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130365840-130366340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130366341-130366841 Neighboring gene VISTA enhancer hs737 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:130424650-130424847 Neighboring gene uncharacterized LOC105378554 Neighboring gene uncharacterized LOC107984185

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085591.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    128628845..128630044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    129554087..129555286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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