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LOC126861136 MED14-independent group 3 enhancer GRCh37_chr11:10004023-10005222 [ Homo sapiens (human) ]

Gene ID: 126861136, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861136
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:10004023-10005222
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9982476..9983675)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (10066873..10068072)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene uncharacterized LOC101928008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4426 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:9884465-9885024 Neighboring gene RNA, U7 small nuclear 28 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9915190-9915690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9915691-9916191 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:9927555-9928139 Neighboring gene glutamate-ammonia ligase pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:10065715-10066914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:10098213-10098818 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3147 Neighboring gene Sharpr-MPRA regulatory region 210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3148 Neighboring gene adrenomedullin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085635.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9982476..9983675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    10066873..10068072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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