U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126861249 CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:69407786-69408985 [ Homo sapiens (human) ]

Gene ID: 126861249, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126861249
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:69407786-69408985
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69593018..69594217)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69609879..69611078)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69290349-69291033 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69291034-69291718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69291719-69292403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69295265-69296231 Neighboring gene long intergenic non-protein coding RNA 2747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69299754-69300291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69300292-69300830 Neighboring gene long intergenic non-protein coding RNA 1488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69304402-69305070 Neighboring gene VISTA enhancer hs1920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69314370-69314904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69316310-69316810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69324803-69325431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69325432-69326060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69328322-69328822 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69335476-69336233 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69336234-69336990 Neighboring gene MPRA-validated peak1326 silencer Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69350505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69351691-69352192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69352193-69352692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69353440-69354100 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69354185 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69367118 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69370584 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69371642 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69375393 Neighboring gene Sharpr-MPRA regulatory region 10534 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:69388143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69390821-69391383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69415650-69416150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69416151-69416651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69430076-69430934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69452808-69453748 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69453749-69454687 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69456195-69456897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69458416-69459160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69462137-69462880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69463625-69464368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69469698-69470635 Neighboring gene uncharacterized LOC124902704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69472515-69473242 Neighboring gene cyclin D1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085748.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69593018..69594217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69609879..69611078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases