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LOC126861256 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:71009949-71011148 [ Homo sapiens (human) ]

Gene ID: 126861256, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861256
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:71009949-71011148
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861256 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71298903..71300102)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71225293..71226492)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70732137-70732636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70737866-70738791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70751855-70752356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70752357-70752856 Neighboring gene microRNA 3664 Neighboring gene MPRA-validated peak1330 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70819961-70820462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70820463-70820962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70850430-70851309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70851310-70852188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70909445-70910320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70910321-70911195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70916186-70916782 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70916783-70917377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70925881-70926462 Neighboring gene Sharpr-MPRA regulatory region 1844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70955112-70955856 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70955857-70956600 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70956601-70957344 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70957345-70958088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70979141-70979640 Neighboring gene uncharacterized LOC124902706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71012233-71012890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71054609-71055108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3706 Neighboring gene actin, aortic smooth muscle-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71100061-71100562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71100563-71101062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71107588-71108289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71110671-71111514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71113580-71114080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3707 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71159471-71159972 Neighboring gene actin epsilon 1, pseudogene Neighboring gene 7-dehydrocholesterol reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085755.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    71298903..71300102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    71225293..71226492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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