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LOC126861258 MED14-independent group 3 enhancer GRCh37_chr11:72012242-72013441 [ Homo sapiens (human) ]

Gene ID: 126861258, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861258
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:72012242-72013441
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72301198..72302397)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72227658..72228857)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 1 pseudogene Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 pseudogene Neighboring gene uncharacterized LOC124902708 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:72019508-72019989 Neighboring gene ClpB family mitochondrial disaggregase Neighboring gene Sharpr-MPRA regulatory region 1135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72026127-72026628 Neighboring gene uncharacterized LOC112268077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5190 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:72129073-72129760 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72129761-72130448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72130449-72131135 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:72131818-72133017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72145720-72146526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3719 Neighboring gene ADP-ribosyltransferase 2B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085757.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72301198..72302397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    72227658..72228857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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