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LOC126862020 CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:90757747-90758946 [ Homo sapiens (human) ]

Gene ID: 126862020, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862020
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:90757747-90758946
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862020 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (90291403..90292602)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (84515673..84516872)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene glutaredoxin pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr14:90625508-90626009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:90650653-90651154 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:90722543-90723072 and GRCh37_chr14:90723073-90723600 Neighboring gene proteasome 26S subunit, ATPase 1 Neighboring gene NRDE-2, necessary for RNA interference, domain containing Neighboring gene Sharpr-MPRA regulatory region 379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:90792221-90792722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:90792723-90793222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6006 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:90819601-90819793 Neighboring gene uncharacterized LOC105370618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:90848618-90849145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:90849146-90849672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:90849673-90850199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8879 Neighboring gene ribosomal protein L21 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 5900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8881 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:90870785-90871984 Neighboring gene calmodulin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086518.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    90291403..90292602
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    84515673..84516872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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