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LOC126862063 MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237 [ Homo sapiens (human) ]

Gene ID: 126862063, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862063
Gene description
MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102707701..102708900)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96944047..96945246)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103050544-103051072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103057589-103058404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6127 Neighboring gene RNA, 7SL, cytoplasmic 546, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9076 Neighboring gene REST corepressor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:103119605-103120104 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103129073-103129810 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103188411-103189610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103204471-103204972 Neighboring gene uncharacterized LOC124903390 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103213106-103213279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103216089-103216923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103224133-103224633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103236826-103237330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103237331-103237835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6131 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103249335-103249487 Neighboring gene small nucleolar RNA U13 Neighboring gene TNF receptor associated factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086561.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102707701..102708900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96944047..96945246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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