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LOC126862166 MED14-independent group 3 enhancer GRCh37_chr15:70145330-70146529 [ Homo sapiens (human) ]

Gene ID: 126862166, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862166
Gene description
MED14-independent group 3 enhancer GRCh37_chr15:70145330-70146529
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69852991..69854190)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67675196..67676395)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr15:70097321-70097517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70106110-70106935 Neighboring gene gem nuclear organelle associated protein 8 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70112963-70113484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70114007-70114528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70135718-70136359 Neighboring gene long intergenic non-protein coding RNA 593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70142408-70142923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70208404-70208905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70211725-70212348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70212349-70212971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70235717-70236216 Neighboring gene uncharacterized LOC101929129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70282987-70283875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70292527-70293028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70307241-70307744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9667 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40838 Neighboring gene uncharacterized LOC124903518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70324572-70325184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086664.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    69852991..69854190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    67675196..67676395
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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