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LOC126862179 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74676645-74677844 [ Homo sapiens (human) ]

Gene ID: 126862179, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862179
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74676645-74677844
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74384119..74385503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72251844..72253228)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 11 subfamily A member 1 Neighboring gene uncharacterized LOC124903524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6646 Neighboring gene CYP11A1 promoter region Neighboring gene peptidylprolyl isomerase A pseudogene 46 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74667008-74667555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74670820-74671320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74675326-74675826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9753 Neighboring gene long intergenic non-protein coding RNA 2255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678372-74678912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74678913-74679452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679453-74679994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74679995-74680534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74680535-74681075 Neighboring gene CRISPRi-validated cis-regulatory element chr15.2230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9758 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:74688843-74690042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74692014-74692514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74693783-74694283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74695428-74696393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74701581-74702081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74703990-74704490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74704491-74704991 Neighboring gene semaphorin 7A (JohnMiltonHagen blood group) Neighboring gene microRNA 6881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74713934-74714565 Neighboring gene Sharpr-MPRA regulatory region 521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74715829-74716459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74734123-74734632 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74734999-74735183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74735145-74735654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74741828-74742328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74751547-74752066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74752067-74752586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:74752742-74753588 Neighboring gene ubiquitin like 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 9754
  • ATAC-STARR-seq lymphoblastoid active region 9755

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086677.2 

    Range
    101..1485
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74384119..74385503
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160016.1 Reference GRCh38.p14 PATCHES

    Range
    213388..214772
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72251844..72253228
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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