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LOC126862243 BRD4-independent group 4 enhancer GRCh37_chr15:98957206-98958405 [ Homo sapiens (human) ]

Gene ID: 126862243, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862243
Gene description
BRD4-independent group 4 enhancer GRCh37_chr15:98957206-98958405
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (98413977..98415176)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (96178359..96179557)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:98635045-98635606 Neighboring gene uncharacterized LOC105371010 Neighboring gene long intergenic non-protein coding RNA 1582 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:98721449-98722648 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42793 Neighboring gene NANOG hESC enhancer GRCh37_chr15:98775748-98776249 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:98776351-98777550 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42800 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:98800245-98801098 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42822 Neighboring gene long intergenic non-protein coding RNA 2351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:98959168-98959668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:98959669-98960169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:98964233-98964808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:98965386-98965961 Neighboring gene Sharpr-MPRA regulatory regions 4169 and 6096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6853 Neighboring gene zinc finger CCHC-type containing 9 pseudogene Neighboring gene protein FAM169B Neighboring gene ReSE screen-validated silencer GRCh37_chr15:99031875-99032074 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:99056319-99056501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99122390-99122890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99122891-99123391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99135615-99136114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99143220-99143720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99143721-99144221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99148269-99148769 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:99189870-99190491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6857 Neighboring gene IGF1R antisense imprinted non-protein coding RNA Neighboring gene insulin like growth factor 1 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086741.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    98413977..98415176
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    96178359..96179557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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