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LOC126862462 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:2795785-2796984 [ Homo sapiens (human) ]

Gene ID: 126862462, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862462
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:2795785-2796984
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2892491..2894017)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2780829..2782355)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2615428-2616323 Neighboring gene coiled-coil domain containing 92B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8011 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2658382-2658591 Neighboring gene microRNA 1253 Neighboring gene RAP1 GTPase activating protein 2 Neighboring gene MPRA-validated peak2687 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:2710701-2711302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2735911-2736411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2745057-2745556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2751037-2751628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2752811-2753401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2759426-2759948 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2775362-2776117 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2776873-2777628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2779141-2779895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2782927-2783844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2786639-2787300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2788221-2788974 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2802958-2803170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2805995-2806657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2806658-2807320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2815301-2815822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2818323-2819076 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2824404-2824976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2824977-2825547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2828640-2829358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2829359-2830075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2834060-2834806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2834807-2835551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2835552-2836297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2842489-2843006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2843524-2844040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2850356-2850876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2850877-2851397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2851398-2851918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2859760-2860388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2860389-2861018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2863407-2863948 Neighboring gene uncharacterized LOC101927911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2868522-2869022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2869023-2869523 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2898072-2898248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2898498-2898998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2914073-2914574 Neighboring gene olfactory receptor family 1 subfamily D member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2796528-2797311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086960.2 

    Range
    101..1627
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    2892491..2894017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    2780829..2782355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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