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LOC126862491 MED14-independent group 3 enhancer GRCh37_chr17:10108420-10109619 [ Homo sapiens (human) ]

Gene ID: 126862491, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862491
Gene description
MED14-independent group 3 enhancer GRCh37_chr17:10108420-10109619
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (10205103..10206302)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (10112855..10114054)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9802365-9802866 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9828374-9829300 Neighboring gene recoverin Neighboring gene ReSE screen-validated silencer GRCh37_chr17:9862137-9862330 Neighboring gene growth arrest specific 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9884467-9884968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929360-9929865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9929866-9930370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9936551-9937052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9937053-9937552 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9964299-9964800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9971697-9972196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10010547-10011088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10020585-10021114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10021115-10021644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10022175-10022702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10022877-10023835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10030567-10031284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074140-10074966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10074967-10075792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:10076620-10077445 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:10083873-10084415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10113552-10114271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:10114272-10114990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8200 Neighboring gene RPS27A pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 11916 Neighboring gene uncharacterized LOC107985004 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:10195435-10196634 Neighboring gene Sharpr-MPRA regulatory region 3410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:10212735-10213249 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:10232009-10232227 Neighboring gene myosin heavy chain 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086989.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    10205103..10206302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    10112855..10114054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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