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LOC126862532 CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:31439262-31440461 [ Homo sapiens (human) ]

Gene ID: 126862532, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126862532
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:31439262-31440461
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862532 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (33112244..33113443)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (34058332..34059531)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (31439262..31440461)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31262798-31263448 Neighboring gene Sharpr-MPRA regulatory region 812 Neighboring gene NANOG hESC enhancer GRCh37_chr17:31329363-31329898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31341295-31341796 Neighboring gene transmembrane protein 98 Neighboring gene sperm acrosome associated 3 Neighboring gene uncharacterized LOC105371737 Neighboring gene acid sensing ion channel subunit 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:31519773-31520284 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:31520285-31520795 Neighboring gene uncharacterized LOC124903985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31588469-31588970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31588971-31589470 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:31619340-31619510 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:31689385-31689886 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:31689887-31690386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31707898-31708398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31708399-31708899 Neighboring gene NANOG hESC enhancer GRCh37_chr17:31740081-31740603 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:31779502-31780247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:31795840-31796340 Neighboring gene uncharacterized LOC100506677

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087029.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    33112244..33113443
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    34058332..34059531
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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