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LOC126862641 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73315884-73317083 [ Homo sapiens (human) ]

Gene ID: 126862641, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862641
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73315884-73317083
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75319753..75321002)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76211975..76213224)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MIF4GD divergent transcript Neighboring gene solute carrier family 25 member 19 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:73284659-73285160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8963 Neighboring gene uncharacterized LOC124904059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73297250-73297750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73322960-73323460 Neighboring gene growth factor receptor bound protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73341127-73342118 Neighboring gene ribosomal protein L36a pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73343103-73343271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73346323-73346862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73346863-73347400 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73348169-73348497 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:73376470-73377316 Neighboring gene MPRA-validated peak2996 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:73390107-73391015 Neighboring gene uncharacterized LOC124904060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 12754

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087138.2 

    Range
    101..1350
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75319753..75321002
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76211975..76213224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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