U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862650 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:75250208-75251407 [ Homo sapiens (human) ]

Gene ID: 126862650, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126862650
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:75250208-75251407
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (77254126..77255325)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (78147369..78148568)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SEC14 like lipid binding 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75159437-75159938 Neighboring gene RNA, U4 small nuclear 47, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75181881-75182382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75182383-75182882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75213877-75214400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75217127-75217628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75217629-75218128 Neighboring gene CYCS pseudogene 40 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:75229305-75230504 Neighboring gene Sharpr-MPRA regulatory region 14112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75243257-75244107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75253655-75254312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75254313-75254968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262063-75262564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262565-75263064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75275663-75276310 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75277912-75278075 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:75281897-75283096 Neighboring gene SEPTIN9 divergent transcript Neighboring gene lung adenocarcinoma-associated transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75299804-75300691 Neighboring gene HNF4 motif-containing MPRA enhancer 212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75304718-75305262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75306143-75306644 Neighboring gene septin 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75310435-75311270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75312943-75313778 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75316721-75316933 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75319666-75319839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75322007-75322925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75325959-75326536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75326537-75327112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75352605-75353106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75359740-75360398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75360399-75361055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75371719-75372408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75373534-75374144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75378629-75379166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75379167-75379704 Neighboring gene uncharacterized LOC124904062

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087147.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    77254126..77255325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315955.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    45019..46218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    78147369..78148568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases