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LOC126862666 BRD4-independent group 4 enhancer GRCh37_chr17:78694608-78695807 [ Homo sapiens (human) ]

Gene ID: 126862666, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862666
Gene description
BRD4-independent group 4 enhancer GRCh37_chr17:78694608-78695807
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80720808..80722007)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81622875..81624074)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371922 Neighboring gene Sharpr-MPRA regulatory region 3542 Neighboring gene regulatory associated protein of MTOR complex 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78587247-78587748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78587749-78588248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78589766-78590266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78590267-78590767 Neighboring gene MPRA-validated peak3026 silencer Neighboring gene ribosomal protein L31 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78610889-78611669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78634706-78635206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78635207-78635707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78650012-78650538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78650539-78651063 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:78667505-78668704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78670527-78671054 Neighboring gene Sharpr-MPRA regulatory region 1160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78699572-78700532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12941 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:78717414-78717768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78722091-78722592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78722593-78723092 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:78734834-78736033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78753273-78753773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9110 Neighboring gene uncharacterized LOC101928855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78785069-78785570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78794217-78794820 Neighboring gene uncharacterized LOC124904076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087163.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    80720808..80722007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    81622875..81624074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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