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LOC126862673 CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80877734-80878933 [ Homo sapiens (human) ]

Gene ID: 126862673, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862673
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80877734-80878933
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862673 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82919858..82921057)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83795017..83796216)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tubulin folding cofactor D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80786629-80787475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80795429-80795930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80802695-80803196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80803197-80803696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80807949-80808451 Neighboring gene zinc finger protein 750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80817109-80817884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824049-80824550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824551-80825050 Neighboring gene uncharacterized LOC124904096 Neighboring gene TBCD intron CAGE-defined B cell enhancer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:80833329-80834528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80840561-80841358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80842957-80843755 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:80853679-80853938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80856643-80857144 Neighboring gene uncharacterized LOC124904095 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80935960-80937159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80942083-80942584 Neighboring gene Sharpr-MPRA regulatory region 7018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80968063-80968585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80975436-80976388 Neighboring gene uncharacterized LOC124904094

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087170.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82919858..82921057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    83795017..83796216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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