U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862697 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:11856862-11858061 [ Homo sapiens (human) ]

Gene ID: 126862697, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126862697
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:11856862-11858061
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (11856863..11858062)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (12019121..12020320)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene ASNS pseudogene 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:11775153-11775652 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:11796263-11796399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13096 Neighboring gene Sharpr-MPRA regulatory region 95 Neighboring gene uncharacterized LOC124904251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:11861344-11862250 Neighboring gene charged multivesicular body protein 1B Neighboring gene ReSE screen-validated silencer GRCh37_chr18:11875590-11875801 Neighboring gene uncharacterized LOC124904252 Neighboring gene metallophosphoesterase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

General gene information

Go to the top of the page Help

Other Names

  • H3K27ac hESC enhancer GRCh37_chr18:11857069-11857626

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087194.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    11856863..11858062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    12019121..12020320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases