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LOC126862707 MED14-independent group 3 enhancer GRCh37_chr18:21452354-21453553 [ Homo sapiens (human) ]

Gene ID: 126862707, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862707
Gene description
MED14-independent group 3 enhancer GRCh37_chr18:21452354-21453553
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (23872390..23873589)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (24066658..24067857)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:21268776-21269325 Neighboring gene ribosomal protein S10 pseudogene 27 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21299932-21300432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21300433-21300933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21305921-21306891 Neighboring gene ribosomal protein L23a pseudogene 77 Neighboring gene laminin subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21427116-21427961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21531393-21532253 Neighboring gene MPRA-validated peak3071 silencer Neighboring gene long intergenic non-protein coding RNA 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9361 Neighboring gene TTC39C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9363 Neighboring gene tetratricopeptide repeat domain 39C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087204.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    23872390..23873589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    24066658..24067857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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