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LOC126862722 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:29318221-29319420 [ Homo sapiens (human) ]

Gene ID: 126862722, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862722
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:29318221-29319420
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862722 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (31738258..31739457)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (31928771..31929970)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:29303886-29305085 Neighboring gene leucine rich repeat containing 37 member A7, pseudogene Neighboring gene golgi SNAP receptor complex member 2 pseudogene Neighboring gene solute carrier family 25 member 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13207 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29383595-29384386 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29389007-29389784 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29389785-29390562 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29390563-29391340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:29399375-29399875 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29405731-29406276 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406277-29406822 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406823-29407368 Neighboring gene trafficking protein particle complex subunit 8 Neighboring gene MPRA-validated peak3103 silencer Neighboring gene family with sequence similarity 76 member A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087219.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    31738258..31739457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    31928771..31929970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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