U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862743 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:47135425-47136624 [ Homo sapiens (human) ]

Gene ID: 126862743, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126862743
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:47135425-47136624
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126862743 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (49609055..49610254)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49806873..49808072)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:47026295-47027190 Neighboring gene long intergenic non-protein coding RNA 2837 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:47042044-47042658 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:47057605-47057776 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:47076971-47078170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47088634-47089134 Neighboring gene lipase G, endothelial type Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47138971-47139847 Neighboring gene uncharacterized LOC105372112 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47139848-47140723 Neighboring gene MPRA-validated peak3145 silencer Neighboring gene uncharacterized LOC112268210 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:47185307-47185916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47189661-47190508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47190509-47191354 Neighboring gene single-strand-selective monofunctional uracil-DNA glycosylase 1 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:47249700-47250899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47252155-47252900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47252901-47253644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47283654-47284603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47285800-47286402 Neighboring gene Sharpr-MPRA regulatory region 2051 Neighboring gene acetyl-CoA acyltransferase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087240.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    49609055..49610254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49806873..49808072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases