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LOC126863005 MED14-independent group 3 enhancer GRCh37_chr20:23999092-24000291 [ Homo sapiens (human) ]

Gene ID: 126863005, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863005
Gene description
MED14-independent group 3 enhancer GRCh37_chr20:23999092-24000291
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (24018455..24019654)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (24080198..24081397)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23974385-23975104 Neighboring gene uncharacterized LOC107985438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23975825-23976543 Neighboring gene POM121 transmembrane nucleoporin like 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10846 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:24072588-24072791 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:24083185-24084384 Neighboring gene wound and keratinocyte migration associated lncRNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24093443-24093943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24098080-24098789 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:24098790-24099500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24124334-24124834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12736 Neighboring gene Sharpr-MPRA regulatory region 14939 Neighboring gene long intergenic non-protein coding RNA 1721 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:24192565-24193107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087502.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    24018455..24019654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    24080198..24081397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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