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LOC126863027 BRD4-independent group 4 enhancer GRCh37_chr20:37736157-37737356 [ Homo sapiens (human) ]

Gene ID: 126863027, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863027
Gene description
BRD4-independent group 4 enhancer GRCh37_chr20:37736157-37737356
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (39107514..39108713)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (40838971..40840170)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17876 Neighboring gene family with sequence similarity 83 member D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17878 Neighboring gene DEAH-box helicase 35 Neighboring gene nucleophosmin 1 pseudogene 19 Neighboring gene MPRA-validated peak4214 silencer Neighboring gene Sharpr-MPRA regulatory region 15217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37737834-37738828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37740853-37741354 Neighboring gene uncharacterized LOC107985448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37779519-37780019 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:37819274-37819952 Neighboring gene long intergenic non-protein coding RNA 1734 Neighboring gene VISTA enhancer hs1042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:37898023-37898523 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:37910830-37911508 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:37911509-37912185 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:37918403-37918981 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:37919138-37919677 Neighboring gene autophagy related 3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087524.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    39107514..39108713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    40838971..40840170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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