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LOC126863083 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311 [ Homo sapiens (human) ]

Gene ID: 126863083, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863083
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. A subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62739760..62740959)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64538482..64539681)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SLCO4A1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18212 Neighboring gene solute carrier organic anion transporter family member 4A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18213 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61302735-61303693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61314847-61315390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61315391-61315933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339152-61339665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339666-61340178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340388-61340934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340935-61341479 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61352726-61352918 Neighboring gene neurotensin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61354746-61355285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61366135-61366980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61392433-61393212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61400285-61401016 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659 Neighboring gene uncharacterized LOC105372716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61424450-61425144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K4me1 hESC enhancer GRCh37_chr20:61371292-61371920

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087579.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62739760..62740959
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64538482..64539681
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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