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LOC126863206 BRD4-independent group 4 enhancer GRCh37_chrX:9907403-9908602 [ Homo sapiens (human) ]

Gene ID: 126863206, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863206
Gene description
BRD4-independent group 4 enhancer GRCh37_chrX:9907403-9908602
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (9939363..9940562)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (9521974..9523172)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene shroom family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9793532-9794054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9800056-9800700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9800701-9801344 Neighboring gene Sharpr-MPRA regulatory region 9039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9811123-9812117 Neighboring gene eukaryotic translation initiation factor 5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9824841-9825341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9827950-9828450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9828451-9828951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9833462-9834428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9834429-9835394 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891143-9891644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891645-9892144 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9895839-9896557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9908687-9909186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29405 Neighboring gene claudin 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9981409-9982292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9982293-9983176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10009285-10009817 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10008750-10009284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10014897-10015530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10015531-10016163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10018119-10018742 Neighboring gene WWC family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10050926-10051426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10077459-10078176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10078177-10078894 Neighboring gene Sharpr-MPRA regulatory region 7563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087702.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    9939363..9940562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    9521974..9523172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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