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LOC126863216 CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:16203427-16204626 [ Homo sapiens (human) ]

Gene ID: 126863216, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863216
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:16203427-16204626
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126863216 in Genome Data Viewer
Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16185304..16186503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (15768827..15770026)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20677 Neighboring gene MAGEB17 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:16178523-16179722 Neighboring gene gastrin releasing peptide receptor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:16186339-16187224 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:16197237-16197862 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16204620-16205364 Neighboring gene MAGE family member B17 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:16233634-16234454 Neighboring gene ribosomal protein L6 pseudogene 30 Neighboring gene uncharacterized LOC124905249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29453 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16464669-16465194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:16465195-16465720

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087712.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    16185304..16186503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    15768827..15770026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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