CNR2 cannabinoid receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CNR2provided by HGNC
Official Full Name: cannabinoid receptor 2provided by HGNC
Primary source: HGNC:HGNC:2160
See related: Ensembl:ENSG00000188822 MIM:605051; AllianceGenome:HGNC:2160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CB2; CX5; CB-2
Summary: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 3.7), spleen (RPKM 3.4) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (23870515..23913362, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23705612..23750778, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (24197005..24239852, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.
Title: Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.
Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.
Title: Single nucleotide polymorphisms in the cannabinoid CB(2) receptor: Molecular pharmacology and disease associations.
Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
Title: Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.
Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.
Title: Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.
CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.
Title: CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.
The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions.
Title: The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions.
Neuroprotection and Beyond: The Central Role of CB1 and CB2 Receptors in Stroke Recovery.
Title: Neuroprotection and Beyond: The Central Role of CB1 and CB2 Receptors in Stroke Recovery.
Tumor necrosis factor alpha, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth.
Title: Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth.
Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.
Title: Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.
Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
Title: Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.

Submit: New GeneRIF Correction See all GeneRIFs (244)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic neuronal/glial culture model	PubMed
	env	CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs	PubMed
	env	HIV-1 gp120-induced synapse loss is inhibited by activation of CB2 receptor	PubMed
Tat	tat	CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells	PubMed
	tat	Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution	PubMed
	tat	HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol	PubMed
	tat	CB(2) cannabinoid receptor 2 is involved in HIV-1 Tat-mediated macrophage migration	PubMed
	tat	HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3	PubMed
capsid	gag	Monocyte-derived macrophages treated during differentiation with a CB2 specific agonist show decrease in p24 levels	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D10S275 (e-PCR)
- UniSTS:147992

GDB:435196 (e-PCR)
- UniSTS:157214

D8S2279 (e-PCR)
- UniSTS:473907

D10S2448 (e-PCR)
- UniSTS:474444

L18426 (e-PCR)
- UniSTS:34648

NoName (e-PCR)
- UniSTS:481892

D1S1423 (e-PCR)
- UniSTS:149619

G35510 (e-PCR)
- UniSTS:44150

RH36905 (e-PCR)
- UniSTS:87932

GDB:315881 (e-PCR)
- UniSTS:156545

D13S1552 (e-PCR)
- UniSTS:473481

WIAF-1577 (e-PCR)
- UniSTS:27044

SHGC-74384 (e-PCR)
- UniSTS:52392

RH121875 (e-PCR)
- UniSTS:136619

CNR2 (e-PCR)
- UniSTS:503254

SGC31908 (e-PCR)
- UniSTS:62446

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cannabinoid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cannabinoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of action potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mast cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cannabinoid receptor 2

Names: cannabinoid receptor 2 (macrophage)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001841.3 → NP_001832.1 cannabinoid receptor 2

See identical proteins and their annotated locations for NP_001832.1

Status: REVIEWED

Source sequence(s)

AL590609, BC069722, X74328

Consensus CDS

CCDS245.1

UniProtKB/Swiss-Prot

C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0

Related

ENSP00000363596.4, ENST00000374472.5

Conserved Domains (1) summary

cd15341
Location:34 → 310

7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

23870515..23913362 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540629.4 → XP_011538931.1 cannabinoid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011538931.1

UniProtKB/Swiss-Prot

C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0

Conserved Domains (1) summary

cd15341
Location:34 → 310

7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_047444833.1 → XP_047300789.1 cannabinoid receptor 2 isoform X1

UniProtKB/Swiss-Prot

C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
XM_017000261.3 → XP_016855750.1 cannabinoid receptor 2 isoform X1

UniProtKB/Swiss-Prot

C6ES44, P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0

Conserved Domains (1) summary

cd15341
Location:34 → 310

7tmA_CB2; cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors