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Cit citron [ Mus musculus (house mouse) ]

Gene ID: 12704, updated on 28-Oct-2024

Summary

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Official Symbol
Citprovided by MGI
Official Full Name
citronprovided by MGI
Primary source
MGI:MGI:105313
See related
Ensembl:ENSMUSG00000029516 AllianceGenome:MGI:105313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRIK; Cit-k; CRIK-SK; C030025P15Rik
Summary
Enables protein serine/threonine kinase activity. Involved in generation of neurons and mitotic cell cycle. Acts upstream of or within several processes, including dendrite development; metaphase/anaphase transition of mitotic cell cycle; and negative regulation of dendrite morphogenesis. Located in actin cytoskeleton; ruffle; and vacuole. Is expressed in several structures, including central nervous system; hemolymphoid system gland; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in cortex adult (RPKM 9.3), frontal lobe adult (RPKM 8.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Cit in Genome Data Viewer
Location:
5 F; 5 56.1 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115983284..116147012)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115845224..116008953)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E154 Neighboring gene BICD family like cargo adaptor 1 Neighboring gene STARR-seq mESC enhancer starr_14136 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E430 Neighboring gene predicted gene, 42008 Neighboring gene predicted gene, 36185 Neighboring gene STARR-positive B cell enhancer ABC_E2758 Neighboring gene protein kinase, AMP-activated, beta 1 non-catalytic subunit Neighboring gene predicted gene 13842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the citron kinase gene selectively affects the number and distribution of interneurons in barrelfield cortex. Muzzi P, et al. J Comp Neurol, 2009 Mar 20. PMID 19148892
  2. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Madaule P, et al. Nature, 1998 Jul 30. PMID 9697773
  3. Citron kinase mediates transition from constriction to abscission through its coiled-coil domain. Watanabe S, et al. J Cell Sci, 2013 Apr 15. PMID 23444367
  4. Discs large 5 is required for polarization of citron kinase in mitotic neural precursors. Chang Y, et al. Cell Cycle, 2010 May 15. PMID 20436275, Free PMC Article
  5. RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells. Fu Y, et al. Mol Biol Rep, 2011 Feb. PMID 20369383

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
    Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
  2. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.
    Title: Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.
  3. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.
    Title: Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
  4. p27 has a role in cytokinesis via the regulation of citron-K activity
    Title: p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
  5. CITRON has a role in proliferation of hepatocellular carcinoma cells
    Title: RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.
  6. Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
    Title: Discs large 5 is required for polarization of citron kinase in mitotic neural precursors.
  7. Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.
    Title: Deletion of the citron kinase gene selectively affects the number and distribution of interneurons in barrelfield cortex.
  8. These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
    Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
  9. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase and functions in the control of G(2)/M transition in the hepatocyte cell cycle
    Title: Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes.
  10. Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.
    Title: Role of citron kinase in dendritic morphogenesis of cortical neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in generation of neurons IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of dendrite morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic density protein 95 clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
citron Rho-interacting kinase
Names
citron kinase
citron-N
rho-interacting, serine/threonine-protein kinase 21
NP_031734.3
XP_006530193.1
XP_006530194.1
XP_006530195.1
XP_006530196.1
XP_006530197.1
XP_006530198.1
XP_006530199.1
XP_006530200.1
XP_006530201.1
XP_006530202.1
XP_006530203.1
XP_006530204.1
XP_006530205.1
XP_006530206.1
XP_006530208.1
XP_006530209.1
XP_006530210.1
XP_006530212.1
XP_006530213.1
XP_006530214.1
XP_006530215.1
XP_006530216.1
XP_011246465.1
XP_017176130.1
XP_017176132.1
XP_017176133.1
XP_017176134.1
XP_017176135.1
XP_030109958.1
XP_030109959.1
XP_030109960.1
XP_036020657.1
XP_036020658.1
XP_036020659.1
XP_036020660.1
XP_036020661.1
XP_036020662.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007708.3 → NP_031734.3  citron Rho-interacting kinase

    See identical proteins and their annotated locations for NP_031734.3

    Status: VALIDATED

    Source sequence(s)
    AC115795, AC162461
    Consensus CDS
    CCDS19597.1
    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    UniProtKB/TrEMBL
    E9QL53
    Related
    ENSMUSP00000062049.9, ENSMUST00000051704.15
    Conserved Domains (5) summary
    smart00036
    Location:1619 → 1915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1470 → 1589
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1319
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1389 → 1437
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115983284..116147012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530131.3 → XP_006530194.1  citron Rho-interacting kinase isoform X1

    See identical proteins and their annotated locations for XP_006530194.1

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  2. XM_030254099.2 → XP_030109959.1  citron Rho-interacting kinase isoform X8

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1658 → 1954
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1494 → 1613
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1413 → 1461
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  3. XM_006530146.4 → XP_006530209.1  citron Rho-interacting kinase isoform X17

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    cl02434
    Location:1687 → 1743
    CNH; CNH domain

  4. XM_036164765.1 → XP_036020658.1  citron Rho-interacting kinase isoform X18

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    COG1196
    Location:473 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1508 → 1627
    PH; PH domain
    cd20814
    Location:1423 → 1478
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
    cl02434
    Location:1672 → 1728
    CNH; CNH domain

  5. XM_006530130.5 → XP_006530193.1  citron Rho-interacting kinase isoform X1

    See identical proteins and their annotated locations for XP_006530193.1

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  6. XM_006530134.5 → XP_006530197.1  citron Rho-interacting kinase isoform X2

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  7. XM_006530137.5 → XP_006530200.1  citron Rho-interacting kinase isoform X5

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1672 → 1968
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  8. XM_036164764.1 → XP_036020657.1  citron Rho-interacting kinase isoform X6

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1672 → 1968
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1523 → 1642
    PH; PH domain
    cd20814
    Location:1438 → 1493
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  9. XM_006530136.5 → XP_006530199.1  citron Rho-interacting kinase isoform X4

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1672 → 1968
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1508 → 1627
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1427 → 1475
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  10. XM_030254100.2 → XP_030109960.1  citron Rho-interacting kinase isoform X9

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1657 → 1953
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1508 → 1627
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1427 → 1475
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  11. XM_006530135.5 → XP_006530198.1  citron Rho-interacting kinase isoform X3

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1678 → 1974
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1514 → 1633
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1363
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1433 → 1481
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  12. XM_030254098.1 → XP_030109958.1  citron Rho-interacting kinase isoform X7

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1663 → 1959
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1499 → 1618
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1418 → 1466
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  13. XM_006530139.5 → XP_006530202.1  citron Rho-interacting kinase isoform X10

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1645 → 1941
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1481 → 1600
    PH; Pleckstrin homology domain
    COG1196
    Location:555 → 1330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1400 → 1448
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  14. XM_006530138.5 → XP_006530201.1  citron Rho-interacting kinase isoform X8

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1658 → 1954
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1494 → 1613
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1413 → 1461
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  15. XM_006530140.4 → XP_006530203.1  citron Rho-interacting kinase isoform X11

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    UniProtKB/TrEMBL
    D3YU89
    Related
    ENSMUSP00000099620.4, ENSMUST00000102560.7
    Conserved Domains (5) summary
    smart00036
    Location:1634 → 1930
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1485 → 1604
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1334
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1404 → 1452
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  16. XM_006530141.4 → XP_006530204.1  citron Rho-interacting kinase isoform X12

    See identical proteins and their annotated locations for XP_006530204.1

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    UniProtKB/TrEMBL
    E9QL53
    Conserved Domains (5) summary
    smart00036
    Location:1619 → 1915
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1470 → 1589
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1319
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1389 → 1437
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  17. XM_006530143.4 → XP_006530206.1  citron Rho-interacting kinase isoform X14

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    UniProtKB/TrEMBL
    D3Z1U0
    Related
    ENSMUSP00000107639.3, ENSMUST00000112008.9
    Conserved Domains (5) summary
    smart00036
    Location:1592 → 1888
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1443 → 1562
    PH; Pleckstrin homology domain
    COG1196
    Location:455 → 1292
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1362 → 1410
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  18. XM_006530145.4 → XP_006530208.1  citron Rho-interacting kinase isoform X15

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    UniProtKB/TrEMBL
    F6SBR5
    Related
    ENSMUSP00000115802.3, ENSMUST00000141101.5
    Conserved Domains (5) summary
    smart00036
    Location:1577 → 1873
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1428 → 1547
    PH; Pleckstrin homology domain
    COG1196
    Location:480 → 1282
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1347 → 1395
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  19. XM_011248163.3 → XP_011246465.1  citron Rho-interacting kinase isoform X16

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1577 → 1873
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1428 → 1547
    PH; Pleckstrin homology domain
    COG1196
    Location:480 → 1282
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1347 → 1395
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  20. XM_006530142.4 → XP_006530205.1  citron Rho-interacting kinase isoform X13

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  21. XM_006530133.4 → XP_006530196.1  citron Rho-interacting kinase isoform X1

    See identical proteins and their annotated locations for XP_006530196.1

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  22. XM_036164766.1 → XP_036020659.1  citron Rho-interacting kinase isoform X19

    Conserved Domains (5) summary
    PTZ00449
    Location:1554 → 1645
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1242 → 1538
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:28 → 927
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00169
    Location:1078 → 1197
    PH; PH domain
    cd20814
    Location:993 → 1048
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  23. XM_006530132.5 → XP_006530195.1  citron Rho-interacting kinase isoform X1

    See identical proteins and their annotated locations for XP_006530195.1

    UniProtKB/Swiss-Prot
    O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1
    Conserved Domains (5) summary
    smart00036
    Location:1687 → 1983
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1523 → 1642
    PH; Pleckstrin homology domain
    COG1196
    Location:473 → 1372
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1442 → 1490
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:96 → 421
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  24. XM_006530150.5 → XP_006530213.1  citron Rho-interacting kinase isoform X22

    Conserved Domains (5) summary
    PTZ00449
    Location:1533 → 1624
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1221 → 1517
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1057 → 1176
    PH; Pleckstrin homology domain
    COG1196
    Location:7 → 906
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:976 → 1024
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  25. XM_036164768.1 → XP_036020661.1  citron Rho-interacting kinase isoform X24

    Conserved Domains (5) summary
    PTZ00449
    Location:1504 → 1595
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1192 → 1488
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:7 → 877
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00169
    Location:1028 → 1147
    PH; PH domain
    cd20814
    Location:943 → 998
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  26. XM_006530149.5 → XP_006530212.1  citron Rho-interacting kinase isoform X21

    Conserved Domains (5) summary
    PTZ00449
    Location:1541 → 1632
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1229 → 1525
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1065 → 1184
    PH; Pleckstrin homology domain
    COG1196
    Location:15 → 914
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:984 → 1032
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  27. XM_017320644.3 → XP_017176133.1  citron Rho-interacting kinase isoform X26

    Conserved Domains (5) summary
    PTZ00449
    Location:1499 → 1590
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1187 → 1483
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1023 → 1142
    PH; Pleckstrin homology domain
    COG1196
    Location:97 → 872
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:942 → 990
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  28. XM_017320645.3 → XP_017176134.1  citron Rho-interacting kinase isoform X27

    Conserved Domains (5) summary
    PTZ00449
    Location:1490 → 1581
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1178 → 1474
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1014 → 1133
    PH; Pleckstrin homology domain
    COG1196
    Location:5 → 863
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:933 → 981
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  29. XM_017320641.3 → XP_017176130.1  citron Rho-interacting kinase isoform X23

    Conserved Domains (5) summary
    PTZ00449
    Location:1512 → 1603
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1200 → 1496
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1036 → 1155
    PH; Pleckstrin homology domain
    COG1196
    Location:15 → 885
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:955 → 1003
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  30. XM_036164769.1 → XP_036020662.1  citron Rho-interacting kinase isoform X29

    Conserved Domains (5) summary
    PTZ00449
    Location:1482 → 1573
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1170 → 1466
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:15 → 870
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00169
    Location:1021 → 1140
    PH; PH domain
    cd20814
    Location:936 → 991
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  31. XM_017320643.3 → XP_017176132.1  citron Rho-interacting kinase isoform X25

    Conserved Domains (5) summary
    PTZ00449
    Location:1503 → 1594
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1191 → 1487
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1027 → 1146
    PH; Pleckstrin homology domain
    COG1196
    Location:15 → 876
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:946 → 994
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  32. XM_017320646.3 → XP_017176135.1  citron Rho-interacting kinase isoform X28

    Conserved Domains (5) summary
    PTZ00449
    Location:1488 → 1579
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1176 → 1472
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1012 → 1131
    PH; Pleckstrin homology domain
    COG1196
    Location:15 → 861
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:931 → 979
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  33. XM_006530151.5 → XP_006530214.1  citron Rho-interacting kinase isoform X30

    See identical proteins and their annotated locations for XP_006530214.1

    UniProtKB/Swiss-Prot
    P49025
    Conserved Domains (5) summary
    PTZ00449
    Location:1473 → 1564
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1161 → 1457
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1012 → 1131
    PH; Pleckstrin homology domain
    COG1196
    Location:15 → 861
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:931 → 979
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  34. XM_006530147.2 → XP_006530210.1  citron Rho-interacting kinase isoform X19

    See identical proteins and their annotated locations for XP_006530210.1

    Conserved Domains (5) summary
    PTZ00449
    Location:1554 → 1645
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1242 → 1538
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:28 → 927
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00169
    Location:1078 → 1197
    PH; PH domain
    cd20814
    Location:993 → 1048
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  35. XM_036164767.1 → XP_036020660.1  citron Rho-interacting kinase isoform X20

    Conserved Domains (5) summary
    PTZ00449
    Location:1545 → 1636
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:1233 → 1529
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG1196
    Location:28 → 918
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00169
    Location:1069 → 1188
    PH; PH domain
    cd20814
    Location:984 → 1039
    CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

  36. XM_006530152.2 → XP_006530215.1  citron Rho-interacting kinase isoform X31

    Conserved Domains (5) summary
    PTZ00449
    Location:1185 → 1276
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00036
    Location:873 → 1169
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:709 → 828
    PH; Pleckstrin homology domain
    COG1196
    Location:2 → 580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:628 → 676
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  37. XM_006530153.1 → XP_006530216.1  citron Rho-interacting kinase isoform X32

    Related
    ENSMUST00000122877.8
    Conserved Domains (4) summary
    smart00036
    Location:849 → 1145
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:700 → 819
    PH; Pleckstrin homology domain
    COG1196
    Location:2 → 571
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:619 → 667
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49025.3 GenPept UniProtKB/Swiss-Prot:P49025

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