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LOC127268858 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41128965-41129622 [ Homo sapiens (human) ]

Gene ID: 127268858, updated on 27-Aug-2024

Summary

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Gene symbol
LOC127268858
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41128965-41129622
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40663293..40663950)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40532479..40533136)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378673 Neighboring gene general transcription factor IIF subunit 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 730 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:41093974-41095173 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene uncharacterized LOC105378675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 852 Neighboring gene NFYC antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 733 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:41174578-41175204 Neighboring gene nuclear transcription factor Y subunit gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41180095-41180734 Neighboring gene microRNA 30e

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_090719.1 

    Range
    101..758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40663293..40663950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40532479..40533136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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