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LOC127270433 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154909644-154910585 [ Homo sapiens (human) ]

Gene ID: 127270433, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127270433
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154909644-154910585
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127270433 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154937168..154938109)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154076529..154077470)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154909644..154910585)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC124904429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154702946-154703755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154703756-154704564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154708005-154708564 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:154708837-154710036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154714090-154714590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154721874-154722377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1783 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154785391-154786050 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154786051-154786708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154812853-154813354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1786 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:154831699-154832199 Neighboring gene Sharpr-MPRA regulatory region 4766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154834547-154835222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154835223-154835896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154836963-154837852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154840581-154841100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154842508-154843464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154849802-154850387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154850973-154851557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154883471-154883971 Neighboring gene uncharacterized LOC105371449 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154908701-154909643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154914379-154915254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154917055-154917556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154924461-154924960 Neighboring gene phosphomevalonate kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154931761-154932260 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:154933865-154934605 and GRCh37_chr1:154934606-154935345 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene PYGO2 and SHC1 antisense RNA 1 Neighboring gene pygopus family PHD finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_092285.1 

    Range
    101..1042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    154937168..154938109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154076529..154077470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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