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LOC127270853 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:174352088-174352652 [ Homo sapiens (human) ]

Gene ID: 127270853, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127270853
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:174352088-174352652
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127270853 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (174382950..174383514)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173740918..173741482)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (174352088..174352652)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene RAB GTPase activating protein 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:174207528-174208157 Neighboring gene MPRA-validated peak467 silencer Neighboring gene forty-two-three domain containing 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:174472688-174472877 Neighboring gene G protein-coupled receptor 52 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:174564621-174565222 Neighboring gene Sharpr-MPRA regulatory region 10542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2123 Neighboring gene BANF1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_092705.1 

    Range
    101..665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    174382950..174383514
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    173740918..173741482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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