U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127272474 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8723860-8724539 [ Homo sapiens (human) ]

Gene ID: 127272474, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127272474
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8723860-8724539
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127272474 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8583683..8584409)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8607339..8608065)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8723813..8724539)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 298 Neighboring gene uncharacterized LOC124907727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8160164-8160664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8160665-8161165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8168595-8169096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8169097-8169596 Neighboring gene long intergenic non-protein coding RNA 299 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:8226605-8227804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8289994-8290494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8290495-8290995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8299141-8299642 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:8299609-8299785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8329342-8329842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:8333701-8334276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15252 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8393901-8394772 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:8403947-8404533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8417861-8418362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8421562-8422062 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8440800-8441356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8532754-8533299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8580531-8581030 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:8587230-8588429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8635675-8636175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11124 Neighboring gene CRISPRi-validated cis-regulatory element chr2.183 Neighboring gene CRISPRi-validated cis-regulatory element chr2.184 Neighboring gene CRISPRi-validated cis-regulatory element chr2.185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8683848-8684354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8684355-8684861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15268 Neighboring gene Sharpr-MPRA regulatory region 11674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8712051-8712630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15270 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8724540-8725218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8727462-8728114 Neighboring gene long intergenic non-protein coding RNA 1814 Neighboring gene uncharacterized LOC105373411 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:8773308-8774507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8777331-8777854 Neighboring gene VISTA enhancer hs1527 Neighboring gene SNRPE pseudogene 5 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:8802380-8803579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8815873-8816791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8816792-8817709 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:8818423-8818956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8818957-8819490 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8821385-8821888 Neighboring gene ID2 antisense RNA 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 11125

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_094325.2 

    Range
    101..827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    8583683..8584409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    8607339..8608065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases