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LOC127274266 H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165 [ Homo sapiens (human) ]

Gene ID: 127274266, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127274266
Gene description
H3K27ac hESC enhancer GRCh37_chr2:101869253-101870165
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes two accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127274266 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101252661..101253703)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101711364..101712406)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101869123..101870165)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11819 Neighboring gene BBSome interacting protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16299 Neighboring gene VISTA enhancer hs1933 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:101740925-101742124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11820 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101768548-101769048 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101775410-101776609 Neighboring gene TBC1D8 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:101779352-101779869 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101866397-101866896 Neighboring gene uncharacterized LOC124906053 Neighboring gene uncharacterized LOC105373511 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 11821
  • ATAC-STARR-seq lymphoblastoid silent region 11822

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096116.2 

    Range
    101..1143
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101252661..101253703
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101711364..101712406
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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