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LOC127274279 OCT4-NANOG hESC enhancer GRCh37_chr2:102509916-102510686 [ Homo sapiens (human) ]

Gene ID: 127274279, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127274279
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr2:102509916-102510686
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127274279 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101893454..101894224)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102351704..102352474)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102509916..102510686)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102150441-102151230 Neighboring gene uncharacterized LOC105373514 Neighboring gene PRCP pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:102182961-102183536 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:102224391-102224936 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:102225481-102226024 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:102226025-102226568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16302 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102304849-102305051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16304 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:102358485-102359214 Neighboring gene Sharpr-MPRA regulatory region 8953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102422933-102423868 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102424513-102425121 Neighboring gene Sharpr-MPRA regulatory region 3767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102552199-102552715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102599375-102599875 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102637443-102637636 Neighboring gene interleukin 1 receptor type 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096129.1 

    Range
    101..871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101893454..101894224
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102351704..102352474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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