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LOC127274408 H3K27ac hESC enhancer GRCh37_chr2:111435817-111436737 [ Homo sapiens (human) ]

Gene ID: 127274408, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127274408
Gene description
H3K27ac hESC enhancer GRCh37_chr2:111435817-111436737
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127274408 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110678240..110679160)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111101153..111102073)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111435817..111436737)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16371 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111434896-111435816 Neighboring gene uncharacterized LOC105373554 Neighboring gene small nucleolar RNA, C/D box 132 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111445059-111446030 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111446031-111447002 Neighboring gene Sharpr-MPRA regulatory region 12654 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Neighboring gene uncharacterized LOC124906064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16374 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:111510337-111510838 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111529706-111530207 Neighboring gene acyl-CoA oxidase like Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111553982-111554181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:111556532-111557731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111558229-111558834 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:111559681-111560360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111570488-111570988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111594132-111595120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16375 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111616831-111617348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111623769-111624474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111624475-111625179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111626664-111627274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111631628-111632251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111634418-111635282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111661014-111661514 Neighboring gene ribosomal protein L5 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 16372
  • ATAC-STARR-seq lymphoblastoid active region 16373

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096258.1 

    Range
    101..1021
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110678240..110679160
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    111101153..111102073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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