U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127275289 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175661185-175662046 [ Homo sapiens (human) ]

Gene ID: 127275289, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC127275289
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175661185-175662046
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127275289 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174796457..174797318)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (175285209..175286070)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12130 Neighboring gene Sharpr-MPRA regulatory region 14969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175629201-175629700 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175646775-175647382 Neighboring gene uncharacterized LOC124907908 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175652041-175652856 Neighboring gene Sharpr-MPRA regulatory region 431 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175660322-175661184 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175679928-175680086 Neighboring gene chimerin 1 Neighboring gene Sharpr-MPRA regulatory region 13906 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:175778728-175779927 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:175788643-175789389 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:175789465-175790079 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175790080-175790693 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:175828782-175829617 Neighboring gene MPRA-validated peak3936 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:175831556-175832392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:175869279-175869825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12131 Neighboring gene RNA, U6 small nuclear 763, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_097137.1 

    Range
    101..962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    174796457..174797318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    175285209..175286070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases