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LOC127276319 H3K27ac hESC enhancer GRCh37_chr2:239196796-239197690 [ Homo sapiens (human) ]

Gene ID: 127276319, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127276319
Gene description
H3K27ac hESC enhancer GRCh37_chr2:239196796-239197690
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127276319 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (238288155..238289049)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (238777894..238778788)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239142883-239143384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239147110-239147678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239149579-239150084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239150085-239150590 Neighboring gene TARDBP pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:239154789-239155988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239156797-239157297 Neighboring gene hes family bHLH transcription factor 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239172424-239172924 Neighboring gene period circadian regulator 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239179613-239180112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239187958-239188582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239190897-239191397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239192245-239192744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239196189-239196711 Neighboring gene uncharacterized LOC112268433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17380 Neighboring gene MPRA-validated peak4101 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239223693-239224192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12496 Neighboring gene TRAF3 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17381 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:239276069-239276272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239317872-239318404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:239318939-239319470 Neighboring gene RNA, U6 small nuclear 234, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 12493

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_098162.1 

    Range
    101..995
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    238288155..238289049
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    238777894..238778788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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