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LOC127398362 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:118725480-118726080 [ Homo sapiens (human) ]

Gene ID: 127398362, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127398362
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:118725480-118726080
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127398362 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (119006633..119007233)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (121726374..121726974)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118725480..118726080)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374060 Neighboring gene uncharacterized LOC105374059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20293 Neighboring gene immunoglobulin superfamily member 11 Neighboring gene IGSF11 antisense RNA 1 Neighboring gene MPRA-validated peak4780 silencer Neighboring gene MPRA-validated peak4781 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:118763719-118764299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:118764300-118764879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:118839208-118839745 Neighboring gene Sharpr-MPRA regulatory region 3599 Neighboring gene testis expressed 55 Neighboring gene uroplakin 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_100331.1 

    Range
    101..701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    119006633..119007233
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    121726374..121726974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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