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LOC127403635 OCT4-NANOG hESC enhancer GRCh37_chr5:118815935-118816518 [ Homo sapiens (human) ]

Gene ID: 127403635, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127403635
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr5:118815935-118816518
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127403635 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (119480240..119480823)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (120001079..120001662)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22989 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118794469-118795121 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:118797267-118797484 Neighboring gene uncharacterized LOC124901215 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:118805521-118806252 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:118806253-118806984 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:118816519-118817102 Neighboring gene Sharpr-MPRA regulatory region 15152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22990 Neighboring gene ribosomal protein L21 pseudogene 58 Neighboring gene fatty acid binding protein 5 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_105584.1 

    Range
    101..684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    119480240..119480823
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    120001079..120001662
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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