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LOC127403906 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:134735167-134735672 [ Homo sapiens (human) ]

Gene ID: 127403906, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127403906
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:134735167-134735672
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127403906 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135399117..135399982)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (135926289..135927154)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134734807..134735672)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PITX1 antisense RNA 1 Neighboring gene uncharacterized LOC124901072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134470142-134471024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134471025-134471907 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:134509397-134509555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134549501-134550001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134563187-134563687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134565392-134565953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134574510-134575316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:134582317-134583516 Neighboring gene long intergenic non-protein coding RNA 2900 Neighboring gene MPRA-validated peak5478 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:134678129-134679328 Neighboring gene macroH2A.1 histone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16375 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:134735673-134736178 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:134739095-134739661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23171 Neighboring gene VISTA enhancer hs1473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134784907-134785408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134785409-134785908 Neighboring gene uncharacterized LOC124901073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23174 Neighboring gene dendritic cell associated nuclear protein 1 Neighboring gene TIFA inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 16376

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_105855.2 

    Range
    101..966
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135399117..135399982
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    135926289..135927154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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