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LOC127404010 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139038513-139039362 [ Homo sapiens (human) ]

Gene ID: 127404010, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127404010
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139038513-139039362
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127404010 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139658928..139659777)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (140183991..140184840)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139038513..139039362)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D2 Neighboring gene H3 histone pseudogene 25 Neighboring gene Sharpr-MPRA regulatory region 3558 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3240 Neighboring gene Sharpr-MPRA regulatory region 4362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139017982-139018548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139030154-139030654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23246 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139040914-139041480 Neighboring gene CXXC finger protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16424 Neighboring gene uncharacterized LOC124901084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139053795-139054348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139058359-139059081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139064529-139065183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16425 Neighboring gene Sharpr-MPRA regulatory region 3182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139077525-139078494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139079969-139080794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139080795-139081619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139088825-139089815 Neighboring gene uncharacterized LOC124901085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16428 Neighboring gene RNA, U6 small nuclear 236, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_105959.1 

    Range
    101..950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139658928..139659777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    140183991..140184840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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