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LOC127404344 NANOG-H3K27ac hESC enhancer GRCh37_chr5:151063929-151064758 [ Homo sapiens (human) ]

Gene ID: 127404344, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127404344
Gene description
NANOG-H3K27ac hESC enhancer GRCh37_chr5:151063929-151064758
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127404344 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (151684368..151685197)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (152223346..152224174)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (151063929..151064758)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82555 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82563 Neighboring gene FAT atypical cadherin 2 Neighboring gene microRNA 6499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150950930-150951442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150974668-150975189 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150998970-150999648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150999649-151000325 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:151003759-151004958 Neighboring gene uncharacterized LOC105378231 Neighboring gene uncharacterized LOC124901116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23460 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:151042798-151043997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:151065587-151066416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:151066417-151067244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:151079020-151079841 Neighboring gene secreted protein acidic and cysteine rich Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16525 Neighboring gene colorectal liver metastasis associated transcript 3 Neighboring gene MPRA-validated peak5542 silencer Neighboring gene Sharpr-MPRA regulatory region 9564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23463 Neighboring gene MPRA-validated peak5544 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23464 Neighboring gene MPRA-validated peak5543 silencer Neighboring gene RN7SK pseudogene 232 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:151109002-151109538 Neighboring gene Sharpr-MPRA regulatory region 608 Neighboring gene Sharpr-MPRA regulatory regions 4972 and 759 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:151124409-151125608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23467 Neighboring gene ATOX1 antisense RNA 1 Neighboring gene antioxidant 1 copper chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_106293.1 

    Range
    101..930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    151684368..151685197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    152223346..152224174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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