U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127404805 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480 [ Homo sapiens (human) ]

Gene ID: 127404805, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127404805
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127404805 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176660687..176661479)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177207249..177208041)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176087688..176088480)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176070445-176071086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176071087-176071726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176072308-176072818 Neighboring gene Sharpr-MPRA regulatory region 4950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176075745-176076614 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene VISTA enhancer hs2007 Neighboring gene uncharacterized LOC124901144 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176093385-176093611 Neighboring gene tetraspanin 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176098601-176099166 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176099167-176099730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176106874-176107834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176107835-176108794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176119741-176120285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176124309-176125132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176126779-176127601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176139283-176140243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176148139-176148638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152218-176152749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152750-176153280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176159360-176160290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176160291-176161220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176167545-176168254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176170772-176171740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176174798-176175456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176176117-176176775 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176211747-176212340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176212935-176213528 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176219277-176220119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176220120-176220961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176225159-176226105 Neighboring gene MPRA-validated peak5589 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176257203-176258159 Neighboring gene unc-5 netrin receptor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176271727-176272558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176284513-176285014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176295664-176296411 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176299555-176299736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176302473-176303396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176306956-176307321 Neighboring gene hexokinase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 23690

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_106750.2 

    Range
    101..893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176660687..176661479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177207249..177208041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases