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LOC127407270 H3K27ac hESC enhancer GRCh37_chr6:133134673-133135419 [ Homo sapiens (human) ]

Gene ID: 127407270, updated on 12-Sep-2024

Summary

Gene symbol
LOC127407270
Gene description
H3K27ac hESC enhancer GRCh37_chr6:133134673-133135419
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

See LOC127407270 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132813534..132814474)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (134008556..134009496)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133134673..133135613)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25075 Neighboring gene RNA binding motif protein 11 pseudogene 1 Neighboring gene solute carrier family 18 member B1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:133118062-133118562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17553 Neighboring gene uncharacterized LOC107986644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25078 Neighboring gene small nucleolar RNA, C/D box 101 Neighboring gene small nucleolar RNA, C/D box 100 Neighboring gene ribosomal protein S12

Genomic regions, transcripts, and products

General gene information

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 25077

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_109241.2 

    Range
    101..1041
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132813534..132814474
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    134008556..134009496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)