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LOC127408583 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20165845-20166696 [ Homo sapiens (human) ]

Gene ID: 127408583, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127408583
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20165845-20166696
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127408583 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (20126222..20127073)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (20260512..20261363)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927668 Neighboring gene ribosomal protein L21 pseudogene 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25685 Neighboring gene uncharacterized LOC105375181 Neighboring gene NANOG hESC enhancer GRCh37_chr7:20156449-20156975 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20159870-20160723 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20160724-20161576 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20164991-20165844 Neighboring gene MACC1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17988 Neighboring gene MET transcriptional regulator MACC1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25688 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:20256832-20258031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20259517-20260046 Neighboring gene glutamine insufficiency regulator of glutaminase lncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_110551.1 

    Range
    101..952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    20126222..20127073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    20260512..20261363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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