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LOC127458242 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:156432899-156433490 [ Homo sapiens (human) ]

Gene ID: 127458242, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127458242
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:156432899-156433490
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127458242 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (156640205..156640796)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (157827919..157828510)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (156432899..156433490)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNF32 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:156332839-156333338 Neighboring gene long intergenic non-protein coding RNA 244 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:156377606-156378120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:156378121-156378635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:156400279-156400790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:156412155-156412844 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:156412845-156413534 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:156443773-156443992 Neighboring gene ribosomal protein L26 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:156449836-156451035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26910 Neighboring gene RNF32 antisense RNA 1 Neighboring gene ring finger protein 32 Neighboring gene limb development membrane protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26911 Neighboring gene Sharpr-MPRA regulatory region 13578 Neighboring gene ZRS shadow enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26913 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:156613382-156613882 Neighboring gene ZPA regulatory sequence Neighboring gene ReSE screen-validated silencer GRCh37_chr7:156647348-156647581 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:156657413-156657607 Neighboring gene RNA, U4 small nuclear 31, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 18851

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_113015.1 

    Range
    101..692
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    156640205..156640796
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    157827919..157828510
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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